Test Code: ACON+

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Cancer Genomic Profiling

Our panel used to evaluate the mutational status of solid tumors for approved targeted cancer drugs and clinical agents, it covers all coding regions of more than 400 genes governing 12 important cancer signaling pathways.

Next Generation Sequencing, NGS
Our most efficient and comprehensive Next Generation Sequencing based panel provides a strong basis for molecular diagnostic tests.


Cancer Signaling Pathway Analysis
Identify more treatment options with pathway integration
In addition to the target gene of related drug, the downstream genes and other signaling pathways involve other cancer-related genes can be selected to treat patients with these mutations, which avoid drug resistance and provide more therapeutic option.


Specification
Assays Performed Coding exons of more than 400 oncogenes and tumor suppressor genes (Note 1 & 2 )
COSMIC Mutation: > 6,000
Sequencing Mean Depth: >800x
Sample Type: FFPE unstained slide: 10μm/slide x 5 slides +
H&E stained slide (5 μm) x1 slide

Note 1: Additional 4 genes (ALK, RET, ROS1, NTRK1) for fusion genes detection will be included for lung cancer patient (please provide 2 additional unstained slides)
Note 2: Capillary electrophoresis for microsatellite instability (MSI) will be included for colorectal cancer and gastric cancer patients.

Suitable for most patients:
- Newly diagnosed with cancer
- First time to be treated with targeted therapy
- Diagnosed with recurrence or metastasis
- Developed resistance to existing treatment


Gene List

ABL1

CASC5

EML4

GATA2

KMT2C

MYH11

PLAG1

SMARCA4

WH2C1

ABL2

CBL

EP300

GATA3

KMT2D

MYH9

PLCG1

SMARCB1

WRN

ACVR2A

CCND1

EP400

GDNF

KRAS

NBN

PLEKHG5

SMO

WT1

ADAMTS20

CCND2

EPHA3

GNA11

LAMP1

NCOA1

PML

SMUG1

XPA

AFF1

CCNE1

EPHA7

GNAQ

LCK

NCOA2

PMS1

SOCS1

XPC

AFF3

CD79A

EPHB1

GNAS

LIFR

NCOA4

PMS2

SOX11

XPO1

AKAP9

CD79B

EPHB4

GPR124

LPHN3

NF1

POT1

SOX2

XRCC2

AKT1

CDC73

EPHB6

GRM8

LPP

NF2

POU5F1

SRC

ZNF384

AKT2

CDH1

EPBB2

GUCY1A2

LRP1B

NFE2L2

PPARG

SSX1

ZNF521

AKT3

CDH11

ERBB3

HCAR1

LTF

NFKB1

PPP2R1A

STK11


ALK

CDH2

ERBB4

HIF1A

LTK

NFKB2

PRDM1

STK36


AMER1

CDH20

ERCC1

HLF

MAF

NIN

PRKAR1A

SUFU


APC

CDH5

ERCC2

HNF1A

MAFB

NKX2-1

PRKDC

SYK


AR

CDK12

ERCC3

HOOK3

MAGEA1

NLRP1

PSIP1

SYNE1


ARID1A

CDK4

ERCC4

HRAS

MAGI1

NOTCH1

PTCH1

TAF1


ARID2

CDK6

ERCC5

HSP90AA1

MALT1

NOTCH2

PTEN

TAF1L


ARNT

CDK8

ERG

HSP90AB1

MAML2

NOTCH4

PTGS2

TAL1


ASXL1

CDKN2A

ESR1

ICK

MAP2K1

NPM1

PTPN11

TBX22


ATF1

CDKN2B

ETS1

IDH1

MAP2K2

NRAS

PTPRD

TCF12


ATM

CDKN2C

ETV1

IDH2

MAP2K4

NSD1

PTRRT

TCF3


ATR

CEBPA

ETV4

IGF1R

MAP3K7

NTRK1

PAD50

TCF7L1


ATRX

CHEK1

EXT1

IGF2

MAPK1

NTRK3

RAF1

TCF7L2


AURKA

CHEK2

EXT2

IGF2R

MAPK8

NUMA1

RALGDS

TCL1A


AURKB

CIC

EZH2

IKBKB

MARK1

NUP214

RARA

TET1


AURKC

CKS1B

FANCA

IKBKE

MARK4

NUP98

RB1

TET2


AXL

CMPK1

FANCC

IKZF1

MBD1

PAK3

RECQL4

TFE3

BAI3

COL1A1

FANCD2

IL2

MCL1

PALB2

REL

TGFBR2

BAP1

CRBN

FANCF

IL21R

MDM2

PARP1

RET

TGM7

BCL10

CREB1

FANCG

IL6ST

MDM4

PAX3

RHOH

THBS1

BCL11A

CREBBP

FAS

IL7R

MEN1

PAX5

RNASEL

TIMP3

BCL11B

CRKL

FBXW7

ING4

MET

PAX7

RNF2

TLR4

BCL2

CRTC1

FGFR1

IRF4

MITF

PAX8

RNF213

TLX1

BCL2L1

CSF1R

FGFR2

IRS2

MLH1

PBRM1

ROS1

TNFAIP3

BCL2L2

CSMD3

FGFR3

ITGA10

MLLT10

PBX1

RPS6KA2

TNFRSF14

BCL3

CTNNA1

FGFR4

ITGA9

MMP2

PDE4DIP

RRM1

TNK2

BCL6

CTNNB1

FH

ITGB2

MN1

PDGFB

RUNX1

TOP1

BCL9

CYLD

FLCN

ITGB3

MPL

PDGFRA

RUNX1T1

TP53

BCR

CYP2C19

FLI1

JAK1

MER11A

PDGFRB

SAMD9

TPR

BIRC2

CYP2D6

FLT1

JAK2

MSH2

PER1

SBDS

TRIM24

BIRC3

DAXX

FLT3

JAK3

MSH6

PGAP3

SDHA

TRIM33

BIRC3

DCC

FLT4

JUN

MTOR

PHOX2B

SDHB

TRIP11

BLM

DDB2

FN1

KAT6A

MTR

PIK3C2B

SDHC

TRRAP

BLNK

DDIT3

FOXL2

KAT6B

MTRR

PIK3CA

SDHD

TSC1

BMPR1A

DDR2

FOXO1

KDM5C

MUC1

PIK3CB

SEPT9

TSC2

BRAF

DEK

FOXO3

KDM6A

MUTYH

PIK3CD

SETD2

TSHR

BRD3

DICER1

FOXP1

KDR

MYB

PIK3CG

SF3B1

UBR5

BRIP1

DNMT3A

FOXP4

KEAP1

MYC

PIK3R1

SGK1

UGT1A1

BTK

DPYD

FZR1

KIT

MYCL

PIK3R2

SH2D1A

USP9X

BUB1B

DST

G6PD

KLF6

MYCN

PIM1

SMAD2

VHL

CARD11

EGFR

GATA1

KMT2B

MYD88

PKHD1

SMAD4

WAS





Test Methodology:

N/A


Specimen Required: 

FFPE



Turnaround Time : 

Maximum to 6 weeks